反应详情

4-[4-(2,4-Dichloro-phenyl)-thiazol-2-yl]-2′-nitro-biphenyl-2-carboxylic acid (24 mg, 8%) was prepared from 2′-nitro-4-thiocarbamoyl-biphenyl-2-carboxylic acid methyl ester (which may be prepared as described for Intermediate 4) and 2-bromo-2′,4′-dichloroacetophenone (available from Oakwood Products, Inc.) using the procedure described for the preparation of Example 1. 1H NMR (300 MHz, DMSO-d6) δ 13.16 (s, 1H), 8.55 (d, J=1.4 Hz, 1H), 8.29 (s, 1H), 8.23 (d, J=8.0 Hz, 1H), 8.14 (d, J=7.9 Hz, 1H), 8.05 (d, J=8.4 Hz, 1H), 7.57-7.78 (m, 4H), 7.43 (t, J=8.3 Hz, 2H).

1. customdescribed for the preparation of Example 1