2-Bromo-1-(3,4-dichlorophenyl)ethanone → HCID 71506886, compound

Participants

Reaction Steps

4-[4-(3,4-Dichloro-phenyl)-thiazol-2-yl]-2′-nitro-biphenyl-2-carboxylic acid (109 mg, 37%) was prepared from 2′-nitro-4-thiocarbamoyl-biphenyl-2-carboxylic acid methyl ester (which may be prepared as described for Intermediate 4) and 2-bromo-3′,4′-dichloroacetophenone (available from Oakwood Products, Inc.) using the procedure described for the preparation of Example 1. The compound of Example 15 has the same formula as the compound of Example 16. 1H NMR (300 MHz, DMSO-d6) δ 13.18 (s, 1H), 8.56 (s, 1H), 8.47 (s, 1H), 8.26-8.32 (m, 2H), 8.15 (d, J=8.2 Hz, 1H), 8.07 (d, J=8.4 Hz, 1H), 8.03 (d, J=8.6 Hz, 1H), 7.41-7.81 (m, 5H).

Provenance & Evidence