2-Bromo-2'-fluoroacetophenone → HCID 71536629, compound

Participants

Reaction Steps

4-[4-(2-Fluoro-phenyl)-thiazol-2-yl]-2′-nitro-biphenyl-2-carboxylic acid (46 mg, 18%) was prepared from 2′-nitro-4-thiocarbamoyl-biphenyl-2-carboxylic acid methyl ester (which may be prepared as described for Intermediate 4) and 2-fluorophenacyl bromide (available from Matrix Scientific) using the procedure described for the preparation of Example 18 except that the entire 4 mL of water was added at the beginning of the hydrolysis step rather than being added in two portions. 1H NMR (300 MHz, DMSO-d6) δ 8.57 (d, J=1.8 Hz, 1H), 8.12-8.30 (m, 4H), 7.61-7.80 (m, 2H), 7.34-7.50 (m, 5H).

Provenance & Evidence