3-Fluorophenacyl bromide → HCID 71536630, compound

Participants

Reaction Steps

4-[4-(3-Fluoro-phenyl)-thiazol-2-yl]-2′-nitro-biphenyl-2-carboxylic acid (150 mg, 57%) was prepared from 2′-nitro-4-thiocarbamoyl-biphenyl-2-carboxylic acid methyl ester (which may be prepared as described for Intermediate 4) and 3-fluorophenacyl bromide (available from Aldrich Chemical Company, Inc.) using the procedure described for the preparation of Example 18 except that the entire 4 mL of water was added at the beginning of the hydrolysis step rather than being added in two portions. 1H NMR (300 MHz, DMSO-d6) δ 13.14 (br s, 1H), 8.58 (d, J=1.8 Hz, 1H), 8.25-8.28 (m, 2H), 8.10-8.17 (m, 3H), 7.63-7.82 (m, 2H), 7.30-7.48 (m, 4H).

Provenance & Evidence