2-(4-Methoxy-2-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane → 4-[4-(3,4-Dichloro-phenyl)-thiazol-2-yl]-4'-methoxy-2'-nitro-biphenyl-2-carboxylic acid

참여 물질

반응 단계

4-[4-(3,4-Dichloro-phenyl)-thiazol-2-yl]-4′-methoxy-2′-nitro-biphenyl-2-carboxylic acid was prepared in 1% yield (for two steps) from 2-bromo-5-[4-(3,4-dichloro-phenyl)-thiazol-2-yl]-benzoic acid methyl ester (which may be prepared as described for Intermediate 6) and 2-(4-methoxy-2-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (available from Combi-Blocks Inc.) using General Procedure A for Suzuki Coupling and Hydrolysis in Parallel Mode. 1H NMR (300 MHz, DMSO-d6) δ 8.55 (s, 1H), 8.49 (s, 1H), 8.45 (s, 1H), 8.31-8.36 (m, 1H), 8.27 (d, J=7.9 Hz, 1H), 8.03-8.13 (m, 1H), 7.73-7.80 (m, 1H), 7.67 (s, 1H), 7.45 (d, J=8.1 Hz, 1H), 7.37 (d, J=4.5 Hz, 1H), 3.92 (s, 3H).

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