Bromomethyl 2-methoxyphenyl ketone → HCID 71536904, compound

Participants

Reaction Steps

4-[4-(2-Methoxy-phenyl)-thiazol-2-yl]-2′-nitro-biphenyl-2-carboxylic acid (183 mg, 67%) was prepared from 2′-nitro-4-thiocarbamoyl-biphenyl-2-carboxylic acid methyl ester (which may be prepared as described for Intermediate 4) and 2-bromo-2′-methoxyacetophenone (available from ASDI Incorporated) using the procedure described for the preparation of Example 1. 1H NMR (300 MHz, DMSO-d6) δ 13.13 (s, 1H), 8.57 (d, J=1.9 Hz, 1H), 8.13-8.31 (m, 4H), 7.63-7.81 (m, 2H), 7.35-7.47 (m, 3H), 7.18 (d, J=8.3 Hz, 1H), 7.10 (t, J=7.6 Hz, 1H).

Provenance & Evidence