Bromomethyl 4-methoxyphenyl ketone → HCID 86679844, compound

HRID 1519288Notes

Reaction equation

Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][CH:6]=1)=O.[CH3:13][O:14][C:15]([C:17]1[C:18]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=2[N+:32]([O-:34])=[O:33])=[CH:19][CH:20]=[C:21]([C:23](=[S:25])[NH2:24])[CH:22]=1)=[O:16]>O1CCOCC1>[CH3:13][O:14][C:15]([C:17]1[C:18]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=2[N+:32]([O-:34])=[O:33])=[CH:19][CH:20]=[C:21]([C:23]2[S:25][CH:2]=[C:3]([C:5]3[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][CH:6]=3)[N:24]=2)[CH:22]=1)=[O:16]

Participants

Conditions

Temperature: 40 °C

Procedure

2-Bromo-4′-methoxyacetophenone (available from Oakwood Products, Inc.; 144.3 mg, 0.63 mmol) was added to a suspension of 2′-nitro-4-thiocarbamoyl-biphenyl-2-carboxylic acid methyl ester (which may be prepared as described for Intermediate 4; 200 mg, 0.63 mmol) in dioxane (4 mL), and the resulting mixture was stirred at 40° C. for 16 h. The precipitate was collected by filtration (187 mg) and used directly in the next step without purification.

Workup

filtrationThe precipitate was collected by filtration (187 mg)
customused directly in the next step without purification

Sources & evidence

ORD record: ord-96c73893423b4a9b926d3c10b9555b23
Source dataset: uspto-grants-2015_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09073881B2

Reaction notes

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