4-(Bromoacetyl)pyridine hydrobromide → HCID 71535814, compound

Participants

Reaction Steps

2′-Nitro-4-(4-pyridin-4-yl-thiazol-2-yl)-biphenyl-2-carboxylic acid (195 mg, 77%) was prepared from 2′-nitro-4-thiocarbamoyl-biphenyl-2-carboxylic acid methyl ester (which may be prepared as described for Intermediate 4) and 4-(bromoacetyl)pyridine hydrobromide (available from Oakwood Products, Inc.) using the procedure described for the preparation of Example 1. 1H NMR (300 MHz, DMSO-d6) δ 13.14 (s, 1H), 8.68 (d, J=5.2 Hz, 2H), 8.61 (s, 1H), 8.58 (d, J=1.1 Hz, 1H), 8.28 (dd, J=7.9, 0.9 Hz, 1H), 8.14 (d, J=8.2 Hz, 1H), 8.02 (d, J=5.4 Hz, 2H), 7.78 (t, J=7.5 Hz, 1H), 7.65 (t, J=7.6 Hz, 1H), 7.41-7.49 (m, 2H).

Provenance & Evidence