2-Bromo-1-(thiophen-3-yl)ethan-1-one → HCID 71536082, compound

Participants

Reaction Steps

2′-Nitro-4-(4-thiophen-3-yl-thiazol-2-yl)-biphenyl-2-carboxylic acid (50 mg, 19%) was prepared from 2′-nitro-4-thiocarbamoyl-biphenyl-2-carboxylic acid methyl ester (which may be prepared as described for Intermediate 4) and 2-bromo-1-(3-thienyl)-1-ethanone (available from Maybridge) using the procedure described for the preparation of Example 1. 1H NMR (300 MHz, DMSO-d6) δ 13.13 (s, 1H), 8.54 (d, J=1.7 Hz, 1H), 8.23 (dd, J=7.8, 1.8 Hz, 1H), 8.04-8.15 (m, 3H), 7.78 (t, J=6.8 Hz, 1H), 7.62-7.69 (m, 3H), 7.44 (t, J=8.1 Hz, 2H).

Provenance & Evidence