4-Nitrophenylboronic acid → HCID 71538882, 화합물

참여 물질

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Using the conditions of General Procedure B for Suzuki Coupling and Hydrolysis in Parallel Mode, 2-bromo-5-[4-(3,4-dichloro-phenyl)-thiazol-2-yl]-benzoic acid methyl ester (which may be prepared as described for Intermediate 6; 89 mg, 0.2 mmol) was reacted with 4-nitrophenylboronic acid (available from Combi-Blocks Inc.; 67 mg, 0.4 mmol). The resulting ester was hydrolyzed and the acid was purified to give 4-[4-(3,4-dichloro-phenyl)-thiazol-2-yl]-4′-nitro-biphenyl-2-carboxylic acid (17 mg, 18%). 1H NMR (400 MHz, DMSO-d6) δ 13.35 (br s, 3H), 8.50 (s, 1H) 8.47 (s, 1H), 8.34 (s, 1H), 8.27-8.32 (m, 2H), 8.10 (d, J=8.5 Hz, 1H), 7.77 (d, J=6.8 Hz, 1H), 7.68 (d, J=7.0 Hz, 2H), 7.61 (d, J=6.5 Hz, 1H).

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