反应详情

Using the conditions of General Procedure C for Suzuki Coupling and Hydrolysis in Parallel Mode, 2-bromo-5-[4-(3,4-dichloro-phenyl)-thiazol-2-yl]-benzoic acid methyl ester (which may be prepared as described for Intermediate 6; 111 mg, 0.25 mmol) was reacted with 2-ethoxypyrimidine-5-boronic acid (available from Combi-Blocks Inc.; 84 mg, 0.5 mmol). The resulting ester was hydrolyzed and the acid was purified to give 5-[4-(3,4-dichloro-phenyl)-thiazol-2-yl]-2-(2-ethoxy-pyrimidin-5-yl)-benzoic acid (3 mg, 3%). LCMS analysis indicated that the material was ˜69% pure, as measured by UV at 214 nm. LRMS m/z 471.8 (M+H+).

1. customthe acid was purified