4-Methoxy-2-(trifluoromethyl)phenylboronic acid → HCID 71535529, compound

Participants

Reaction Steps

Using the conditions of General Procedure A for Suzuki Coupling and Hydrolysis in Parallel Mode, 2-bromo-5-[4-(3,4-dichloro-phenyl)-thiazol-2-yl]-benzoic acid methyl ester (which may be prepared as described for Intermediate 6; 111 mg, 0.25 mmol) was reacted with 4-methoxy-2-(trifluoromethyl)phenylboronic acid (available from Combi-Blocks Inc.; 110 mg, 0.5 mmol). The resulting ester was hydrolyzed and the acid was purified to give 4-[4-(3,4-dichloro-phenyl)-thiazol-2-yl]-4′-methoxy-2′-trifluoromethyl-biphenyl-2-carboxylic acid (8 mg, 6%). 1H NMR (300 MHz, DMSO-d6) δ 12.97 (br s, 1H), 8.54 (s, 1H), 8.48 (s, 1H), 8.34 (s, 1H), 8.23 (d, J=7.5 Hz, 1H), 8.09 (d, J=8.7 Hz, 1H), 7.77 (d, J=8.5 Hz, 1H), 7.41 (d, J=7.9 Hz, 1H), 7.26 (s, 3H), 3.88 (s, 3H).

Provenance & Evidence