2-Methoxyphenylboronic acid → HCID 71535532, compound

Participants

Reaction Steps

Using the conditions of General Procedure B for Suzuki Coupling and Hydrolysis in Parallel Mode, 2-bromo-5-[4-(3,4-dichloro-phenyl)-thiazol-2-yl]-benzoic acid methyl ester (which may be prepared as described for Intermediate 6; 89 mg, 0.2 mmol) was reacted with 2-methoxyphenylboronic acid (available from Frontier Scientific, Inc.; 61 mg, 0.4 mmol). The resulting ester was hydrolyzed and the acid was purified to give 4-[4-(3,4-dichloro-phenyl)-thiazol-2-yl]-2′-methoxy-biphenyl-2-carboxylic acid (36 mg, 39%). 1H NMR (400 MHz, DMSO-d6) δ 12.75 (br s, 1H), 8.45 (s, 1H), 8.31-8.37 (m, 2H), 8.21 (d, J=8.0 Hz, 1H), 8.09 (d, J=8.3 Hz, 1H), 7.77 (d, J=8.5 Hz, 1H), 7.46 (d, J=8.0 Hz, 1H), 7.36 (t, J=7.8 Hz, 1H), 7.27 (d, J=7.5 Hz, 1H), 7.04 (d, J=7.3 Hz, 2H), 3.69 (s, 3H).

Provenance & Evidence