2-Cyanophenylboronic acid → HCID 86679855, compound

Participants

Reaction Steps

Using the conditions of General Procedure B for Suzuki Coupling and Hydrolysis in Parallel Mode, 2-bromo-5-[4-(3,4-dichloro-phenyl)-thiazol-2-yl]-benzoic acid methyl ester (which may be prepared as described for Intermediate 6; 89 mg, 0.2 mmol) was reacted with 2-cyanophenylboronic acid (available from Aldrich Chemical Company, Inc.; 59 mg, 0.4 mmol). The resulting ester was hydrolyzed and the acid was purified to give 2′-cyano-4-[4-(3,4-dichloro-phenyl)-thiazol-2-yl]-biphenyl-2-carboxylic acid (2 mg, 1%). The compound of Example 111 has the same formula as the compound of Example 112. LCMS analysis indicated that the material was ˜94% pure, as measured by UV at 214 nm. LRMS m/z 450.8 (M+H+).

Provenance & Evidence