5-Acetyl-2-chlorophenylboronic acid → HCID 86679860, compound

Participants

Reaction Steps

5′-Acetyl-2′-chloro-4-[4-(3,4-dichloro-phenyl)-thiazol-2-yl]-biphenyl-2-carboxylic acid was prepared in 7% yield (for two steps) from 2-bromo-5-[4-(3,4-dichloro-phenyl)-thiazol-2-yl]-benzoic acid methyl ester (which may be prepared as described for Intermediate 6) and 5-acetyl-2-chlorophenylboronic acid (available from Combi-Blocks Inc.) using General Procedure A for Suzuki Coupling and Hydrolysis in Parallel Mode. 1H NMR (300 MHz, DMSO-d6) δ 13.14 (s, 1H), 8.58 (d, J=1.9 Hz, 1H), 8.50 (s, 1H), 8.30-8.38 (m, 2H), 8.10 (dd, J=8.4, 2.0 Hz, 1H), 7.98 (dd, J=8.3, 2.1 Hz, 1H), 7.90 (d, J=2.1 Hz, 1H), 7.78 (d, J=8.5 Hz, 1H), 7.69 (d, J=8.5 Hz, 1H), 7.51 (d, J=8.1 Hz, 1H), 2.62 (s, 3H).

Provenance & Evidence