[2-Chloro-4-(trifluoromethyl)phenyl]boronic acid → HCID 86679868, compound

Participants

Reaction Steps

Using the conditions of General Procedure A for Suzuki Coupling and Hydrolysis in Parallel Mode, 2-bromo-5-[4-(3,4-dichloro-phenyl)-thiazol-2-yl]-benzoic acid methyl ester (which may be prepared as described for Intermediate 6; 111 mg, 0.25 mmol) was reacted with 2-chloro-4-(trifluoromethyl)phenylboronic acid (available from Combi-Blocks Inc.; 100 mg, 0.5 mmol). The resulting ester was hydrolyzed and the acid was purified to give 2′-chloro-4-[4-(3,4-dichloro-phenyl)-thiazol-2-yl]-4′-trifluoromethyl-biphenyl-2-carboxylic acid (2 mg, 2%). LCMS analysis indicated that the material was ˜100% pure, as measured by UV at 214 nm.

Provenance & Evidence