反应详情

A solution of 4-(2-hydroxyethyl)naphthalene-1-carbonitrile (25 mg, 0.13 mmol) in DCM (4 mL) was treated with Dess-Martin periodinane (75 mg, 0.18 mmol) and was stirred at room temperature for 3 hours. The reaction was quenched by partitioning with DCM and water containing sodium bicarbonate and sodium thiosulfate (3×). The organic layer was then washed with brine, dried over sodium sulfate and evaporated to give the title aldehyde as an oil which was used directly in subsequent reductive amination reaction.

1. customThe reaction was quenched
2. customby partitioning with DCM and water
3. additioncontaining sodium bicarbonate and sodium thiosulfate (3×)
4. washThe organic layer was then washed with brine
5. dry with materialdried over sodium sulfate
6. customevaporated