HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 4-(2-{4-[2-(4-Nitrophenyl)ethyl]piperazin-1-yl}ethyl)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 1-[2-(4-Bromophenyl)ethyl]-4-[2-(4-nitrophenyl)ethyl]piperazine | HCID 67513412 | — |
| Catalyst | Zinc cyanide (Zn(CN)2) | HCID 11186 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Product | 4-(2-{4-[2-(4-Nitrophenyl)ethyl]piperazin-1-yl}ethyl)benzonitrile | HCID 68071450 | — |
Reaction Steps
A solution of 1-[2-(4-bromophenyl)ethyl]-4-[2-(4-nitrophenyl)ethyl]piperazine (100 mg, 0.24 mmol), Zinc cyanide (84 mg, 0.72 mmol), and tetrakis(triphenylphosphine)palladium in DMF (1 mL) was heated to 85° C. for 1 hour. LC showed formation of the desired product, which was separated by mass-directed HPLC. LC-MS (IE, m/z): 365 (M+1)+. (0.079 μM)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09073882B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-92dd5019d15e42659483e794d8e2cc5a |
| Source note | uspto-grants-2015_07 |