HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1519563Generated: November 3, 2026
Potassium Carbonate → HCID 56971324, compound
https://huagongshe.com/reaction/1519563
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Nitrophenethyl bromide | HCID 79266 | — |
| Reactant | (1S,4S)-2,5-Diazabicyclo[2.2.1]heptane dihydrobromide | HCID 14612497 | — |
| Catalyst | Tetrabutylammonium Iodide | HCID 67553 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 56971324 | HCID 56971324 | — |
Reaction Steps
A mixture of (1S,4S)-2,5-diazabicyclo[2.2.1]heptane dihydrobromide (60 mg, 0.23 mmol), 1-(2-bromoethyl)-4-nitrobenzene (210 mg, 0.92 mmol), tetrabutylammonium iodide (8.5 mg, 0.023 mmol), and K2CO3 (128 mg, 0.92 mmol) in DMF (2 mL) was heated to 60° C. for 16 hours. LC showed formation of the desired product, which was separated by mass-directed HPLC. LC-MS (IE, m/z): 397 [M+1]+. (0.11 μM)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09073882B2 |
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| Source dataset | uspto-grants-2015_07 |
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| ORD ID | ord-d75e27392a0c4c4280e87847c61c443e |
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| Source note | uspto-grants-2015_07 |
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