Triethylamine → 5-{2-[4-(5,6,7,8-Tetrahydronaphtho[2,3-c][1,2,5]oxadiazol-6-yl)piperazin-1-yl]ethyl}-2-benzofuran-1(3H)-one

Participants

Reaction Conditions

Reaction Steps

To a solution of 6-Piperazin-1-yl-5,6,7,8-tetrahydronaphtho[2,3-c][1,2,5]oxadiazole hydrochloride (20 mg, 0.068 mmol), 5-(2-bromoethyl)-2-benzofuran-1(3H)-one (33 mg, 0.14 mmol), and tetrabutylammonium iodide (2.5 mg, 6.8 umol) in DMF (2 mL) was added triethylamine (0.028 mL, 0.20 mmol). The mixture was heated to 55° C. for 6 hours. LC showed formation of the desired product, which was separated by mass-directed HPLC. LC-MS (IE, m/z): 419 [M+1]+. (0.21 μM)

Provenance & Evidence