2-Methoxy-4-(2-oxopropyl)benzonitrile → 2-Methoxy-4-[2-[4-[2-(1-oxo-3H-isobenzofuran-5-yl)ethyl]piperazin-1-yl]propyl]benzonitrile

HRID 1519613Notes

Reaction equation

HRID 1519613 reaction equation
Cl.[N:2]1([CH2:8][CH2:9][C:10]2[CH:19]=[CH:18][C:13]3[C:14](=[O:17])[O:15][CH2:16][C:12]=3[CH:11]=2)[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[CH3:20][O:21][C:22]1[CH:29]=[C:28]([CH2:30][C:31](=O)[CH3:32])[CH:27]=[CH:26][C:23]=1[C:24]#[N:25]>>[CH3:20][O:21][C:22]1[CH:29]=[C:28]([CH2:30][CH:31]([N:5]2[CH2:6][CH2:7][N:2]([CH2:8][CH2:9][C:10]3[CH:11]=[C:12]4[C:13](=[CH:18][CH:19]=3)[C:14](=[O:17])[O:15][CH2:16]4)[CH2:3][CH2:4]2)[CH3:32])[CH:27]=[CH:26][C:23]=1[C:24]#[N:25]

Participants

3

Reactant 2

HCID 666438652-Methoxy-4-(2-oxopropyl)benzonitrileHCID 666467325-(2-piperazin-1-ylethyl)-2-benzofuran-1(3H)-one hydrochloride

Product 1

HCID 680716762-Methoxy-4-[2-[4-[2-(1-oxo-3H-isobenzofuran-5-yl)ethyl]piperazin-1-yl]propyl]benzonitrile

Procedure

2-Methoxy-4-[2-[4-[2-(1-oxo-3H-isobenzofuran-5-yl)ethyl]piperazin-1-yl]propyl]benzonitrile was prepared in a similar fashion to that described for the synthesis of Example 38 starting from 5-[2-(piperazin-1-yl)ethyl]-2-benzofuran-1(3H)-one hydrochloride and 2-methoxy-4-(2-oxopropyl)benzonitrile. LC-MS (IE, m/z): 420.6 [M+1]+. (0.21 μM)

Sources & evidence

ORD record
ord-3f7e2359918e4959b93fde50b3c0f59f
Source dataset
uspto-grants-2015_07
Patent number
US09073882B2

Reaction notes

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