4-methyl-5-(2-piperazin-1-ylethyl)-2-benzofuran-1(3H)-one hydrochloride → HCID 68071338, compound

HRID 1519614Notes

Reaction equation

HRID 1519614 reaction equation
Cl.[CH3:2][C:3]1[C:11]2[CH2:10][O:9][C:8](=[O:12])[C:7]=2[CH:6]=[CH:5][C:4]=1[CH2:13][CH2:14][N:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1.[F:21][CH:22]([F:35])[O:23][C:24]1[CH:31]=[C:30]([CH2:32][CH:33]=O)[CH:29]=[CH:28][C:25]=1[C:26]#[N:27]>>[F:21][CH:22]([F:35])[O:23][C:24]1[CH:31]=[C:30]([CH2:32][CH2:33][N:18]2[CH2:19][CH2:20][N:15]([CH2:14][CH2:13][C:4]3[C:3]([CH3:2])=[C:11]4[C:7](=[CH:6][CH:5]=3)[C:8](=[O:12])[O:9][CH2:10]4)[CH2:16][CH2:17]2)[CH:29]=[CH:28][C:25]=1[C:26]#[N:27]

Participants

3

Reactant 2

HCID 675172294-methyl-5-(2-piperazin-1-ylethyl)-2-benzofuran-1(3H)-one hydrochlorideHCID 86694483HCID 86694483, compound

Product 1

HCID 68071338HCID 68071338, compound

Procedure

2-(Difluoromethoxy)-4-[2-[4-[2-(4-methyl-1-oxo-3H-isobenzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]benzonitrile was prepared in a similar fashion to that described for the synthesis of Example 38 starting from 4-methyl-5-[2-(piperazin-1-yl)ethyl]-2-benzofuran-1(3H)-one hydrochloride and 2-(difluoromethoxy)-4-(2-oxoethyl)benzonitrile. LC-MS (IE, m/z): 456.5 [M+1]+. (0.16 μM)

Sources & evidence

ORD record
ord-2d355f07b4be4cb09221de61612dfb63
Source dataset
uspto-grants-2015_07
Patent number
US09073882B2

Reaction notes

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