Acetic Acid → HCID 56970630, compound

Participants

Reaction Steps

A mixture of 4-methyl-5-(2-piperazin-1-ylethyl)-2-benzofuran-1(3H)-one hydrochloride (62 mg, 0.21 mmol), (1-oxo-1,3-dihydro-2-benzofuran-5-yl)acetaldehyde (40 mg, 0.21 mmol), and sodium triacetoxyborohydride (67 mg, 0.32 mmol) in DCM (5 mL) was stirred overnight with a drop of acetic acid. LC showed formation of the desired product, which was purified by mass-directed HPLC (0.1% TFA in water and acetonitrile). LC-MS (IE, m/z): 435 [M+1]+. (0.076 μM)

Provenance & Evidence