HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1519633Generated: November 2, 2026
Methylamine → Tert-butyl 4-{2-[4-cyano-3-(methylamino)phenyl]ethyl}piperazine-1-carboxylate
https://huagongshe.com/reaction/1519633
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | Tert-butyl 4-[2-(4-cyano-3-fluorophenyl)ethyl]piperazine-1-carboxylate | HCID 67513450 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Tert-butyl 4-{2-[4-cyano-3-(methylamino)phenyl]ethyl}piperazine-1-carboxylate | HCID 67517520 | — |
Reaction Steps
To a solution of tert-butyl 4-[2-(4-cyano-3-fluorophenyl)ethyl]piperazine-1-carboxylate (100 mg, 0.30 mmol) in CH3CN (10 mL) was added aqueous NH2CH3 (10 mL) in a sealed tube, and then heated to 120° C. overnight. The mixture was extracted with EtOAc, washed with brine, dried over anhydrous sodium sulfate and concentrated. The residue was purified via prep-TLC to afford tert-butyl 4-{2-[4-cyano-3-(methylamino)phenyl]ethyl}piperazine-1-carboxylate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09073882B2 |
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| Source dataset | uspto-grants-2015_07 |
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| ORD ID | ord-37f30f25a7214d07b5e4f1d0f7ebc2c2 |
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| Source note | uspto-grants-2015_07 |
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