2-(Isoquinolin-5-YL)acetic acid → Methyl 4-bromo-2-(2-(isoquinolin-5-yl)acetamido)thiophene-3-carboxylate

HRID 1519770Notes

Reaction equation

HRID 1519770 reaction equation
[CH:1]1[C:10]2[C:5](=[C:6]([CH2:11][C:12]([OH:14])=O)[CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][N:2]=1.[NH2:15][C:16]1[S:17][CH:18]=[C:19]([Br:25])[C:20]=1[C:21]([O:23][CH3:24])=[O:22]>>[Br:25][C:19]1[C:20]([C:21]([O:23][CH3:24])=[O:22])=[C:16]([NH:15][C:12](=[O:14])[CH2:11][C:6]2[CH:7]=[CH:8][CH:9]=[C:10]3[C:5]=2[CH:4]=[CH:3][N:2]=[CH:1]3)[S:17][CH:18]=1

Participants

3

Reactant 2

HCID 120187082-(Isoquinolin-5-YL)acetic acidHCID 68754257Methyl 2-amino-4-bromothiophene-3-carboxylate

Product 1

HCID 59636688Methyl 4-bromo-2-(2-(isoquinolin-5-yl)acetamido)thiophene-3-carboxylate

Procedure

The title compound was prepared from 2-(isoquinolin-5-yl)acetic acid (427 mg, 2.18 mmol) and methyl 2-amino-4-bromothiophene-3-carboxylate (514 mg, 2.18 mmol) according to protocol A. Retention time (min)=1.634, method [1], MS(ESI) 405.0 (M+H).

Sources & evidence

ORD record
ord-89ff6738c0f44e44be1babcd9706123f
Source dataset
uspto-grants-2015_07
Patent number
US09073891B2

Reaction notes

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