2-(Quinolin-5-yl)acetic acid → Methyl 4-bromo-2-(2-(quinolin-5-yl)acetamido)thiophene-3-carboxylate

HRID 1519789Notes

Reaction equation

HRID 1519789 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([Br:11])[C:6]=1[C:7]([O:9][CH3:10])=[O:8].[N:12]1[C:21]2[C:16](=[C:17]([CH2:22][C:23](O)=[O:24])[CH:18]=[CH:19][CH:20]=2)[CH:15]=[CH:14][CH:13]=1>>[Br:11][C:5]1[C:6]([C:7]([O:9][CH3:10])=[O:8])=[C:2]([NH:1][C:23](=[O:24])[CH2:22][C:17]2[CH:18]=[CH:19][CH:20]=[C:21]3[C:16]=2[CH:15]=[CH:14][CH:13]=[N:12]3)[S:3][CH:4]=1

Participants

3

Reactant 2

HCID 205339092-(Quinolin-5-yl)acetic acidHCID 68754257Methyl 2-amino-4-bromothiophene-3-carboxylate

Product 1

HCID 68754644Methyl 4-bromo-2-(2-(quinolin-5-yl)acetamido)thiophene-3-carboxylateYield 49%

Procedure

The title compound was prepared from methyl 2-amino-4-bromothiophene-3-carboxylate (660 mg, 2.8 mmol) and 2-(quinolin-5-yl)acetic acid using protocol A. 560 mg (49% yield). Method [1]: rt=1.666 min; MH+ 405/407.

Workup

  1. customrt=1.666 min

Sources & evidence

ORD record
ord-6e2b9937921841478f4b12f1704a7aa8
Source dataset
uspto-grants-2015_07
Patent number
US09073891B2

Reaction notes

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