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Stannane, hydroxytrimethyl- → 2-(7-cyano-2-oxoquinolin-1(2H)-yl)acetic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Stannane, hydroxytrimethyl- | HCID 11217597 | — |
| 反応物 | methyl 2-(7-cyano-2-oxoquinolin-1(2H)-yl)acetate | HCID 68785451 | — |
| 溶媒 | 1,2-Dichloroethane | HCID 11 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2-(7-cyano-2-oxoquinolin-1(2H)-yl)acetic acid | HCID 68782235 | 89% |
反応手順
Trimethyl tin hydroxide (0.388 g, 2.14 mmol) was added to a solution of methyl 2-(7-cyano-2-oxoquinolin-1(2H)-yl)acetate (0.104 g, 0.429 mmol) in 1,2-dichloroethane (5 mL) and the resulting suspension was stirred at reflux for 4 h. The reaction mixture was diluted with dichloromethane and washed with 1N aqueous HCl. Filtration of the organic phase provided 87 mg (89%) of 2-(7-cyano-2-oxoquinolin-1(2H)-yl)acetic acid. Retention time (min)=0.987, method [1], MS(ESI) 229.1 (M+H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09073891B2 |
| 出典データセット | uspto-grants-2015_07 |
| ORD ID | ord-4bd2a82db49d4b1781eb81451c37ed3f |
| 出典メモ | uspto-grants-2015_07 |