HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Hydroxide → 5-Iodo-2-(trifluoromethyl)pyridin-4-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | 4-Chloro-5-iodo-alpha,alpha,alpha-trifluoro-2-picoline | HCID 68756059 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Solvent | Sodium chloride; water | HCID 57417360 | — |
| Product | 5-Iodo-2-(trifluoromethyl)pyridin-4-amine | HCID 68756015 | — |
Reaction Conditions
| Temperature | 110 °C |
|---|
Reaction Steps
Concentrated aqueous ammonium hydroxide (10 mL) was added to a solution of 4-chloro-5-iodo-2-(trifluoromethyl)pyridine (4.11 g, 13.3 mmol) in DMSO in a glass pressure tube. The tube was sealed and placed in an oil bath pre-heated to 110° C. for 48 h. The resulting solution was diluted with brine, extracted with ethyl acetate, dried (Na2SO4), filtered and concentrated under vacuum to give 5-iodo-2-(trifluoromethyl)pyridin-4-amine. Retention time (min)=1.584, method [1], MS(ESI) 289.0 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09073891B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-f0bb4f462a784195b056fdce2f8ef993 |
| Source note | uspto-grants-2015_07 |