HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-(2-(Trifluoromethyl)quinolin-7-yl)acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | tert-Butyl 2-(2-(trifluoromethyl)quinolin-7-yl)acetate | HCID 86649421 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 2-(2-(Trifluoromethyl)quinolin-7-yl)acetic acid | HCID 68754783 | — |
Reaction Steps
tert-Butyl 2-(2-(trifluoromethyl)quinolin-7-yl)acetate was dissolved in glacial AcOH (0.8 mL) and 6 N HCl (0.8 mL) and heated to 80° C. for 2 hr. The reaction mixture was concentrated in vacuo to afford the crude product, which was used without further purification. HPLC method [4], retention time=1.874 min; MS(ESI) 256.1 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09073891B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-385cf604137b4b929efdbbec50b7d912 |
| Source note | uspto-grants-2015_07 |