Formic Acid → 2-(8-Fluoroisoquinolin-5-yl)acetic acid

HRID 1519875Notes

Reaction equation

HRID 1519875 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:12][C:13]([O:15]C(C)(C)C)=[O:14])=[C:6]2[C:11]=1[CH:10]=[N:9][CH:8]=[CH:7]2.C(O)=O>C(Cl)Cl>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:12][C:13]([OH:15])=[O:14])=[C:6]2[C:11]=1[CH:10]=[N:9][CH:8]=[CH:7]2

Participants

4

Reactant 2

HCID 284Formic AcidHCID 68758654Tert-butyl 2-(8-fluoroisoquinolin-5-yl)acetate

Product 1

HCID 687588832-(8-Fluoroisoquinolin-5-yl)acetic acid

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of the above ester (200 mg) in DCM (2 mL) was added formic acid (3 mL). The reaction was sealed with a Teflon cap and heater to 50° C. for 16 h. The solvent was removed and the crude product was used without further purification. LCMS showed an m/z of 206.1 with a retention time of 0.437 min, method [1].

Workup

  1. customcap
  2. customThe solvent was removed
  3. customthe crude product was used without further purification

Sources & evidence

ORD record
ord-d70ea6f0d996406480f11f213702b21d
Source dataset
uspto-grants-2015_07
Patent number
US09073891B2

Reaction notes

Loading…