(Imidazo[1,2-a]pyridin-5-yl)acetic acid → HCID 59636658, compound

HRID 1519892Notes

Reaction equation

HRID 1519892 reaction equation
[N:1]1[CH:2]=[CH:3][N:4]2[C:9]([CH2:10][C:11]([OH:13])=O)=[CH:8][CH:7]=[CH:6][C:5]=12.[Br:14][C:15]1[C:16]([C:21]2[NH:25][N:24]=[CH:23][N:22]=2)=[C:17]([NH2:20])[S:18][CH:19]=1>>[Br:14][C:15]1[C:16]([C:21]2[NH:25][N:24]=[CH:23][N:22]=2)=[C:17]([NH:20][C:11](=[O:13])[CH2:10][C:9]2[N:4]3[CH:3]=[CH:2][N:1]=[C:5]3[CH:6]=[CH:7][CH:8]=2)[S:18][CH:19]=1

Participants

3

Reactant 2

HCID 18936841(Imidazo[1,2-a]pyridin-5-yl)acetic acidHCID 596366864-bromo-3-(4H-1,2,4-triazol-3-yl)thiophen-2-amine

Product 1

HCID 59636658HCID 59636658, compound

Procedure

N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(imidazo[1,2-a]pyridin-5-yl)acetamide was synthesized from 2-(imidazo[1,2-a]pyridin-5-yl)acetic acid and 4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-amine according to protocol A. Retention time (min)=7.958, method [6], MS(ESI) 403.0 (M+H); 1H NMR (300 MHz, CD3OD) δ 8.46 (b s, 1H), 8.35 (d, J=2.2 Hz, 1H), 8.12 (d, J=2.2 Hz, 1H), 8.08-7.96 (m, 2H), 7.58 (d, J=7.2 Hz, 1H), 7.16 (s, 1H), 4.64 (s, 2H).

Sources & evidence

ORD record
ord-9f50ecf734d440118acf27473146edc3
Source dataset
uspto-grants-2015_07
Patent number
US09073891B2

Reaction notes

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