2-(Isoquinolin-5-YL)acetic acid → HCID 46868997, compound

HRID 1519911Notes

Reaction equation

HRID 1519911 reaction equation
[CH:1]1[C:10]2[C:5](=[C:6]([CH2:11][C:12]([OH:14])=O)[CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][N:2]=1.[CH3:15][C:16]1[S:20][C:19]([C:21]2[S:22][CH:23]=[CH:24][C:25]=2[NH2:26])=[N:18][CH:17]=1>>[CH:1]1[C:10]2[C:5](=[C:6]([CH2:11][C:12]([NH:26][C:25]3[CH:24]=[CH:23][S:22][C:21]=3[C:19]3[S:20][C:16]([CH3:15])=[CH:17][N:18]=3)=[O:14])[CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][N:2]=1

Participants

3

Reactant 2

HCID 120187082-(Isoquinolin-5-YL)acetic acidHCID 68756491HCID 68756491, compound

Product 1

HCID 46868997HCID 46868997, compound

Procedure

The title compound was prepared from 2-(isoquinolin-5-yl)acetic acid and 2-(5-methylthiazol-2-yl)thiophen-3-amine using Protocol A. Method[7], MS(ESI) 366.0 [M+H], Retention time=3.157 min; 1H-NMR (300 MHz, CDCl3) δ 11.24 (s, 1H), 9.67 (s, 1H), 8.57 (d, J=6.6 Hz, 1H), 8.30 (d, J=6.6 Hz, 1H), 8.26 (d, J=8.24 Hz, 1H), 8.08-8.04 (m, 2H), 7.96-7.91 (m, 1H), 7.20 (d, J=5.5 Hz, 1H), 6.97 (d, J=1.1 Hz, 1H), 4.31 (s, 2H), 2.43 (d, J=1.1 Hz, 3H).

Sources & evidence

ORD record
ord-f2dfff211fcc44a484e9dd49b2242cf8
Source dataset
uspto-grants-2015_07
Patent number
US09073891B2

Reaction notes

Loading…