2-Chloro-3-nitrothiophene → 2-(Thiazol-4-yl)thiophen-3-amine

HRID 1519912Notes

Reaction equation

HRID 1519912 reaction equation
Cl[C:2]1[S:3][CH:4]=[CH:5][C:6]=1[N+:7]([O-])=O.C([Sn](CCCC)(CCCC)[C:15]1[N:16]=[CH:17][S:18][CH:19]=1)CCC>>[S:18]1[CH:19]=[C:15]([C:2]2[S:3][CH:4]=[CH:5][C:6]=2[NH2:7])[N:16]=[CH:17]1

Participants

3

Reactant 2

HCID 2201862-Chloro-3-nitrothiopheneHCID 27632584-(Tri-n-butylstannyl)thiazole

Product 1

HCID 687553622-(Thiazol-4-yl)thiophen-3-amine

Procedure

This amine was prepared from 2-chloro-3-nitrothiophene using Protocols E and F except that 4-(tributylstannyl)thiazole was used. Method[1], MS(ESI) 183.0 [M+H], Retention time=0.518 min.

Sources & evidence

ORD record
ord-4f300a0a9605493db62ad26bb5e52bc6
Source dataset
uspto-grants-2015_07
Patent number
US09073891B2

Reaction notes

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