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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1519939Generated: October 30, 2026

HCID 68756029, compound → HCID 56675421, compound

https://huagongshe.com/reaction/1519939

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 68756029HCID 68756029—
Reactant2-(2-oxo-6-(trifluoromethyl)quinolin-1(2H)-yl)acetic acidHCID 68759857—
ProductHCID 56675421HCID 56675421—

Reaction Steps

The title compound was synthesized from 5-amino-4-(oxazol-2-yl)thiophene-3-carbonitrile (21 mg, 0.11 mmol) and 2-(2-oxo-6-(trifluoromethyl)quinolin-1(2H)-yl)acetic acid (30 mg, 0.11 mmol) according to protocol A. The product was purified by HPLC. LCMS method [7], retention time=6.70 min; MS(ESI) 445.0 (MH+); 1H NMR (300 MHz, CD3OD) δ 8.19 (d, J=9.8 Hz, 2H), 7.95-7.80 (m, 3H), 7.85 (d, J=1.8 Hz, 1H), 7.08 (d, J=0.8 Hz, 1H), 6.90 (d, J=9.6 Hz, 1H), 5.45 (s, 2H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09073891B2
Source datasetuspto-grants-2015_07
ORD IDord-5a79eae0143446f7a47d40451991ff9a
Source noteuspto-grants-2015_07