HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1519974Generated: November 2, 2026
2-Chloro-3-nitrothiophene → 1-Methyl-4-(3-nitrothiophen-2-yl)-1H-imidazole
https://huagongshe.com/reaction/1519974
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Chloro-3-nitrothiophene | HCID 220186 | — |
| Reactant | 1-Methyl-4-(tributylstannyl)-1H-imidazole | HCID 21901141 | — |
| Product | 1-Methyl-4-(3-nitrothiophen-2-yl)-1H-imidazole | HCID 68784592 | — |
Reaction Steps
The title compound was prepared from 2-chloro-3-nitrothiophene (2.57 g, 15.7 mmol) and 1-methyl-4-(tributylstannyl)-1H-imidazole (8.64 g, 23.3 mmol) using protocol E except the reaction was heated to 90° C. (rather than 95° C.) and was purified by flash chromatography (hexane:ethyl acetate). Method [1] Retention time 0.57 min by HPLC (MH+ 210).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09073891B2 |
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| Source dataset | uspto-grants-2015_07 |
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| ORD ID | ord-4770828d10bb4d8cabd4b8be49830a9e |
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| Source note | uspto-grants-2015_07 |
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