4-Methoxyphenylacetic Acid → HCID 68784451, compound

HRID 1519982Notes

Reaction equation

HRID 1519982 reaction equation
[CH3:1][C:2]1[N:3]([C:13]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:4]=[C:5]([C:7]2[S:8][CH:9]=[CH:10][C:11]=2[NH2:12])[N:6]=1.[CH3:32][O:33][C:34]1[CH:39]=[CH:38][C:37]([CH2:40][C:41](O)=[O:42])=[CH:36][CH:35]=1>>[CH3:32][O:33][C:34]1[CH:39]=[CH:38][C:37]([CH2:40][C:41]([NH:12][C:11]2[CH:10]=[CH:9][S:8][C:7]=2[C:5]2[N:6]=[C:2]([CH3:1])[N:3]([C:13]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=3)[CH:4]=2)=[O:42])=[CH:36][CH:35]=1

Participants

3

Reactant 2

HCID 76904-Methoxyphenylacetic AcidHCID 68757154HCID 68757154, compound

Product 1

HCID 68784451HCID 68784451, compound

Procedure

The title compound was prepared from 2-(2-methyl-1-trityl-1H-imidazol-4-yl)thiophen-3-amine and 2-(4-methoxyphenyl)acetic acid using protocol B (540 mg, 57%). Method [7] Retention time 7.42 min by HPLC (MH+ 570).

Sources & evidence

ORD record
ord-526bc2b886af475cabcf2d92c232248c
Source dataset
uspto-grants-2015_07
Patent number
US09073891B2

Reaction notes

Loading…