4-Methoxyphenylacetic Acid → HCID 52942482, compound

HRID 1520000Notes

Reaction equation

HRID 1520000 reaction equation
[NH2:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[N:7]1[CH2:11][CH2:10][O:9][C:8]1=[O:12].[CH3:13][O:14][C:15]1[CH:20]=[CH:19][C:18]([CH2:21][C:22](O)=[O:23])=[CH:17][CH:16]=1>>[CH3:13][O:14][C:15]1[CH:20]=[CH:19][C:18]([CH2:21][C:22]([NH:1][C:2]2[CH:6]=[CH:5][S:4][C:3]=2[N:7]2[CH2:11][CH2:10][O:9][C:8]2=[O:12])=[O:23])=[CH:17][CH:16]=1

Participants

3

Reactant 2

HCID 76904-Methoxyphenylacetic AcidHCID 68759675HCID 68759675, compound

Product 1

HCID 52942482HCID 52942482, compound

Procedure

The title compound was prepared from 3-(3-aminothiophen-2-yl)oxazolidin-2-one and 2-(4-methoxyphenyl)acetic acid (510 mg, 3.06 mmol) using protocol B. The crude product was purified by HPLC. Method [7] Retention time 2.95 min by HPLC (MH+ 333). 1H NMR (300 MHz, CDCl3) δ 8.14 (broad s, 1H), 7.39 (d, J=5.7 Hz, 1H), 7.27 (d, J=9.0 Hz, 2H), 7.06 (d, J=5.7 Hz, 1H), 6.92 (d, J=9.0 Hz, 2H), 4.47 (m, 2H), 3.89 (m, 2H), 3.83 (s, 3H), 3.64 (s, 2H).

Workup

  1. customThe crude product was purified by HPLC

Sources & evidence

ORD record
ord-936895e756fd4ff49e206c0259dcfc9d
Source dataset
uspto-grants-2015_07
Patent number
US09073891B2

Reaction notes

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