Potassium Carbonate → HCID 118093609, compound

Participants

Reaction Steps

Under nitrogen atmosphere add potassium carbonate (26.4 g, 190.8 mmol) to a solution of 1-(4-hydroxyphenyl)-N-methyl-methanesulfonamide (19.2 g, 95.4 mmol), and 4,6-dichloro-2-methylpyrimidine (15.6 g, 95.4 mmol) in DMSO (192.0 mL). Stir the resulting mixture at room temperature for 2 hours. Pour the mixture into 400 mL of ice/water (1:1 v/v) to induce precipitation. Stir the resulting suspension for 30 minutes. Collect the solid; wash with water; and dry under reduced pressure overnight to provide the title compound as a pale brown solid (27.7 g, 89%). MS (m/z): 328 (M+1).

Provenance & Evidence