Ethanol → HCID 118093612, compound

Participants

Reaction Steps

In a PARR reactor, combine palladium (3.6 g, 10% on charcoal, 1-[4-(6-cyano-2-methyl-pyrimidin-4-yl)oxyphenyl]-N-methyl-methanesulfonamide (18 g, 56.5 mmol), EtOH (270 mL), EtOAc (270 mL), and triethylamine (31.5 mL). Seal the PARR reactor and charge it with hydrogen (400 psi); then shake the reactor at room temperature overnight. Open the reactor and filter the contents through CELITE®; wash the CELITE® pad with EtOH (1000 mL); collect the filtrate; and evaporate the solvent to provide the title compound as a brown solid (11.1 g, 43%). MS (m/z): 323 (M+1). Alternative Preparation 4

Provenance & Evidence