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Following the same procedure adopted for the synthesis of 22, the reaction of nitrile 11 with boronic ester 21 afforded the title compound 24 as an off-white solid (62%). IR (KBr) νmax, cm−1: 3421, 3318 (NH2), 3072 (Ar—H), 2247 (CN), 1691 (C═O), 1616, 1510, 1412 (C═C). 1H-NMR (500 MHz, CDCl3) δ=1.49 (s, 9H, (CH3)3C); 1.71 (br, s, 2H, CH2); 2.45 (br. s, 2H, CH2); 3.61 (m, 2H, CH2); 4.07 (s, 2H CH2); 4.43 (br. s, 2H, NH2); 6.10 (br. s, 1H, CH); 6.71 (d, J=2.2 Hz, 1H, H-2); 6.75 (dd, 1H, J=2.3, 8.6 Hz, H-6); 7.33 (d, J=8.5 Hz, 1H, H-5); 8.01 (br. s, 1H, NH); 13C NMR (125.7 MHz, CDCl3) δ=27.35 (CH2), 28.47 (CH3)3C), 29.73 (CH2), 41.96 (CH2), 79.91 (CH3)3C), 94.63 (aromatic-C), 115.12 (aromatic-C), 117.69 (CN), 133.67 (aromatic-C), 147.42 (aromatic-C), 150.47 (aromatic-C), 155.33 (C═O). Calculated (%) for C17H21N3O2 (299.16); C: 68.20, H: 7.07, N: 14.04. found (%); C: 68.16, H: 7.13, N: 13.97.