N,N-Dimethylaniline → HCID 68194043, compound

Participants

Reaction Conditions

Reaction Steps

POCl3 (2 g, 13.25 mmol) and N,N-dimethylbenzenamine (2.13 g, 17.60 mmol,) were added to a solution of methyl 1-(4-methoxybenzyl)-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-carboxylate (3 g, 8.81 mmol) in toluene (100 ml). The resulting reaction was stirred overnight at 110° C. and concentrated in vacuo. The residue was triturated with methanol (50 ml) and collected by filtration to afford methyl 3-chloro-1-(4-methoxybenzyl)-2-oxo-1,2-dihydroquinoxaline-6-carboxylate as a green solid (2.27 g, 72%).

Provenance & Evidence