Sodium Hydroxide → HCID 57520025, compound

Participants

Reaction Steps

Sodium hydroxide (21.6 mg, 0.54 mmol) was added to a solution of methyl 2-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-(1,2,3,4-tetrahydroquinolin-1-yl)quinoxaline-6-carboxylate (65 mg, crude) in methanol (5 ml) and water (1 ml) and the reaction was stirred overnight at room temperature. The reaction mixture was concentrated in vacuo, the residue was dissolved in water (30 ml), adjusted to pH=5 with hydrochloric acid (3 N), and the precipitate was collected by filtration to afford 2-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-(1,2,3,4-tetrahydroquinolin-1-yl)quinoxaline-6-carboxylic acid as a light yellow solid (31.8 mg).

Provenance & Evidence