Quinoline, 1,2,3,4-tetrahydro-6-methoxy- → HCID 68194188, compound

Participants

Reaction Steps

To a solution of methyl 3-chloro-2-oxo-1,2-dihydroquinoxaline-6-carboxylate (700 mg, crude) in NMP (2 mL) was added 6-methoxy-1,2,3,4-tetrahydroquinoline (1.0 g, 6.13 mmol) with stifling for 3 h at 150° C. The reaction mixture was cooled to room temperature. The product was precipitated by the addition ethyl acetate and the solids were collected by filtration to afford methyl 3-(6-methoxy-1,2,3,4-tetrahydroquinolin-1-yl)-2-oxo-1,2-dihydroquinoxaline-6-carboxylate as a light yellow solid (450 mg), which was used to the next step without further purification.

Provenance & Evidence