Sodium Hydroxide → HCID 57520026, compound

Participants

Reaction Steps

To a solution of methyl 2-(4-fluorophenyl)-3-(6-methoxy-1,2,3,4-tetrahydroquinolin-1-yl)quinoxaline-6-carboxylate (80 mg, 0.18 mmol) in water (1 mL) and MeOH (15 mL) was added sodium hydroxide (29 mg, 0.72 mmol) with stifling overnight at room temperature. The reaction mixture was concentrated under vacuum, dissolved in water (30 mL), adjusted to pH 5 with hydrogen chloride (3 N) to give the precipitation, which was collected by filtration to afford 2-(4-fluorophenyl)-3-(6-methoxy-1,2,3,4-tetrahydroquinolin-1-yl)quinoxaline-6-carboxylic acid as a light yellow solid (50 mg, 64.6%).

Provenance & Evidence