1,2,3,4-Tetrahydroquinoline → HCID 68194205, compound

Participants

Reaction Steps

To a solution of 1,2,3,4-tetrahydroquinoline (1.0 g, 7.51 mmol) in NMP (20 ml) was added methyl 3-chloro-2-oxo-1,2-dihydroquinoxaline-6-carboxylate (670 mg, 2.81 mmol) with stifling 3 h at 130° C. in an oil bath. The product was precipitated with water (80 ml), collected by filtration to afford methyl 2-oxo-3-(1,2,3,4-tetrahydroquinolin-1-yl)-1,2-dihydroquinoxaline-6-carboxylate as a yellow solid (700 mg, 28%).

Provenance & Evidence