Sodium Hydroxide → HCID 68194189, compound

Participants

Reaction Steps

Sodium hydroxide (39 mg, 0.97 mmol) was added to a solution of methyl 7-(6-bromo-1,2,3,4-tetrahydroquinolin-1-yl)-6-(4-fluorophenyl)naphthalene-2-carboxylate (120 mg, 0.24 mmol) in methanol (30 ml) and water (2 ml). The resulting solution was stirred overnight at room temperature and concentrated in vacuo. The residue was dissolved in water (20 ml) and adjusted to pH 4 with hydrochloric acid (3 N) to give the precipitation, which was collected by filtration to afford 7-(6-bromo-1,2,3,4-tetrahydroquinolin-1-yl)-6-(4-fluorophenyl)naphthalene-2-carboxylic acid as a yellow solid (80 mg, 69%).

Provenance & Evidence