Diisopropylethylamine → HCID 68194165, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of methyl 3-chloro-2-oxo-1,2-dihydroquinoxaline-6-carboxylate (420 mg, 1.76 mmol,) in NMP (3 mL) was added DIEA (343 mg, 2.65 mmol), N,N-dimethyl-1,2,3,4-tetrahydroquinolin-6-amine hydrochloride (400 mg, crude) and the reaction was stirred for 2 h at 130° C. in an oil bath. The resulting solution was diluted with water (100 mL), and the solids were collected by filtration to give methyl 3-[6-(dimethylamino)-1,2,3,4-tetrahydroquinolin-1-yl]-2-oxo-1,2-dihydroquinoxaline-6-carboxylate as a red solid (260 mg, 39%).

Provenance & Evidence