Water → HCID 68193979, compound

Participants

Reaction Steps

To a solution of methyl 3-(6-fluoro-1,2,3,4-tetrahydroquinolin-1-yl)-2-(1H-indazol-5-yl)quinoxaline-6-carboxylate (60 mg, 0.13 mmol) in methanol (20 mL) was added sodium hydroxide (15.8 mg, 0.40 mmol) and water (1 mL). The resulting solution was stirred for 3 h at room temperature and concentrated in vacuo. The residue was dissolved in water (20 mL) and adjusted to pH 5 with hydrochloric acid (3 N). The solids were collected by filtration to afford 3-(6-fluoro-1,2,3,4-tetrahydroquinolin-1-yl)-2-(1H-indazol-5-yl)quinoxaline-6-carboxylic acid as a yellow solid (27 mg, 47%).

Provenance & Evidence