Acetic Acid → HCID 68194140, compound

Participants

Reaction Steps

To a solution of methyl 2-(4-fluorophenyl)-3-(7-methoxy-1,2,3,4-tetrahydroquinolin-1-yl)quinoxaline-6-carboxylate (88 mg, 0.20 mmol) in methanol (30 ml) was added sodium hydroxide (32 mg, 0.80 mmol) and water (2 ml). The reaction was stirred for 2 days at room temperature. The resulting solution was diluted with water (15 ml), adjusted to pH 5 with AcOH, extracted with ethyl acetate (2×20 ml) and the organic layers were combined and concentrated in vacuo to afford 2-(4-fluorophenyl)-3-(7-methoxy-1,2,3,4-tetrahydroquinolin-1-yl)quinoxaline-6-carboxylic acid as a yellow solid (59 mg, 69%).

Provenance & Evidence