Hydrochloric Acid → HCID 68194182, compound

Participants

Reaction Steps

To a solution of methyl 3-(7-fluoro-1,2,3,4-tetrahydroquinolin-1-yl)-2-(4-fluorophenyl)quinoxaline-6-carboxylate (120 mg, 0.28 mmol) in methanol (20 ml) was added a solution of sodium hydroxide (44 mg, 1.10 mmol) in water (3 ml). The reaction was stirred overnight at room temperature. The resulting mixture was concentrated in vacuo to give a residue, which was dissolved in water (20 ml) and adjusted to pH 4 with hydrogen chloride (3 N). The solids were collected by filtration to afford 3-(7-fluoro-1,2,3,4-tetrahydroquinolin-1-yl)-2-(4-fluorophenyl)quinoxaline-6-carboxylic acid as a yellow solid (101 mg, 87%).

Provenance & Evidence